fabG

168

beta-ketoacyl-acyl carrier protein reductase

Locus: BSU_15910

Molecular weight: 26.13 kDa

Isoelectric point: 8.09

Protein length: 246 aa

Gene length: 741 bp

Function: fatty acid biosynthesis

Product: beta-ketoacyl-acyl carrier protein reductase

Essential: yes

E.C.: 1.1.1.100

Synonyms: fabG, ylpF

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG1028 (Galperin et al., 2021)

Gene

Coordinates: 1,664,513  1,665,253

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• (3R)-hydroxyacyl-[ACP] + NADP⁺ --> 3-oxoacyl-[ACP] + H⁺ + NADPH (according to UniProt)

Protein family

• Short-chain dehydrogenases/reductases (SDR) family (according to UniProt)

Structure

• 2UVD (PDB) (the enzyme from B. anthracis, 73% identity) PubMed
• P51831 (AlphaFold)

Paralogous protein(s)

• YkvO, YhxC, YusS, YoxD, YhxD, YcdF, YhdF
• YjdA, (30%)
• YmfI, (34%)
• YdaD, (31.1%)
• YtkK, (32,1%)

Expression and Regulation

Operons

• Genes: fapR-plsX-fabD-fabG-acpA

  Description: PubMed

  Regulation

  • ''FapR'': repressed in the absence of malonyl-CoA or malonyl-ACP (FapR) PubMed
  • expression is reduced in motile cells as compared to non-motile cells PubMed

  Regulatory mechanism

  • FapR: repression, PubMed, in fapR regulon
  • ComA: activation, (ComA) PubMed, in comA regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Additional information

• the mRNA is cleaved by RNase III PubMed

References

Reviews

Loading

Original Publications

Loading