sipU

168

signal peptidase I

Locus: BSU_04010

Molecular weight: 21.04 kDa

Isoelectric point: 9.84

Protein length: 187 aa

Gene length: 564 bp

Function: protein secretion

Product: signal peptidase I

Essential: no

Synonyms: sipU, ycsB

Genomic Context

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List of homologs in different organisms, belongs to COG0681 (Galperin et al., 2021)

Gene

Coordinates: 454,029  454,592

The protein

Catalyzed reaction/ biological activity

• Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to UniProt)

Protein family

• peptidase S26 family (according to UniProt)

Structure

• 4NV4 (PDB) (from B. anthracis, 41% identity)
• P42959 (AlphaFold)

Paralogous protein(s)

• SipV, SipT, SipS

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: sipU

  Description: PubMed

Biological materials

Mutant

• BKE04010 (sipU::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTTCCTTCACCCGATGC,  downstream forward: _UP4_TAAAATGCAATGCAAAAAGA
• BKK04010 (sipU::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CAACTTCCTTCACCCGATGC,  downstream forward: _UP4_TAAAATGCAATGCAAAAAGA

Labs working on this gene/protein

• Jan Maarten van Dijl, Groningen, Netherlands

References

Reviews

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Original Publications

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