epeA

168

ABC transporter, ATP-binding protein, export of the mature EpeX epipeptide

Locus: BSU_40150

Molecular weight: 23.74 kDa

Isoelectric point: 8.39

Protein length: 209 aa

Gene length: 630 bp

Function: control of LiaR-LiaS activity

Product: ABC transporter, ATP-binding protein

Essential: no

Synonyms: yydI

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG2401 (Galperin et al., 2021)

Gene

Coordinates: 4,124,963  4,125,592

The protein

Protein family

• ABC transporter superfamily (according to UniProt)

Domains

• ABC transporter domain (aa 1-207) (according to UniProt)

Structure

• 7LB8 (PDB) (aa 5 - 187, E. coli FhuC, 23.8% identity) PubMed
• Q45593 (AlphaFold)

Localization

• membrane associated (via EpeB) PubMed

Expression and Regulation

Operons

• Genes: epeX-epeE-epeP-epeA-epeB

  Description: PubMed

  Regulation

  • repressed during logarithmic growth (AbrB) PubMed

  Expression

  • expression is heterogeneous PubMed

  Regulatory mechanism

  • AbrB: repression, PubMed, in abrB regulon
  • Rok: repression, PubMed, in rok regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-B808 (yydI::erm), available at the NBRP B. subtilis, Japan
• BKE40150 (epeA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATACATACTCCTAGGAA,  downstream forward: _UP4_TAATAAAACAGTGGGGGCTT
• BKK40150 (epeA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATACATACTCCTAGGAA,  downstream forward: _UP4_TAATAAAACAGTGGGGGCTT

References

Reviews

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Original Publications

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