ywcC

168

transcription repressor (TetR family), controls slrA expression

Locus: BSU_38220

Molecular weight: 25.96 kDa

Isoelectric point: 8.47

Protein length: 223 aa

Gene length: 672 bp

Function: control of slrA expression

Product: transcription repressor (TetR family)

Essential: no

Synonyms: ywcC, ipa-33d

Genomic Context

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List of homologs in different organisms, belongs to COG1309 (Galperin et al., 2021)

Gene

Coordinates: 3,922,292 → 3,922,963

Phenotypes of a mutant

• improved colonization on plant roots (inactivating mutations appear during growth on roots) PubMed

The protein

Protein family

• TetR family

Domains

• HTH tetR-type domain (aa 11-71) (according to UniProt)

Structure

• P39601 (AlphaFold)

Expression and Regulation

Operons

• Genes: ywcC-gtcA-galK-galT

  Description: PubMed

  Regulation

  • repressed by glucose (CcpA) PubMed

Biological materials

Mutant

• MGNA-B230 (ywcC::erm), available at the NBRP B. subtilis, Japan
• BKE38220 (ΔywcC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTTTTCTCCTGGCGGT,  downstream forward: _UP4_CAGTGAAGTATAGAGAAATA
• BKK38220 (ΔywcC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATATTTTTCTCCTGGCGGT,  downstream forward: _UP4_CAGTGAAGTATAGAGAAATA

References

Reviews

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Original Publications

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