Difference between revisions of "GlyA"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU36900&redirect=T BSU36900] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/glyA.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/glyA.html] | ||
| Line 94: | Line 95: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU36900&redirect=T BSU36900] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2VGU 2VGU] (complex with L-serine, Geobacillus stearothermophilus), [http://www.rcsb.org/pdb/explore.do?structureId=2VI8 2VI8] (Geobacillus stearothermophilus) | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2VGU 2VGU] (complex with L-serine, Geobacillus stearothermophilus), [http://www.rcsb.org/pdb/explore.do?structureId=2VI8 2VI8] (Geobacillus stearothermophilus) | ||
Revision as of 15:02, 2 April 2014
- Description: serine hydroxymethyltransferase
| Gene name | glyA |
| Synonyms | glyC, ipc-34d |
| Essential | yes PubMed |
| Product | serine hydroxymethyltransferase |
| Function | biosynthesis of glycine |
| Gene expression levels in SubtiExpress: glyA | |
| Metabolic function and regulation of this protein in SubtiPathways: glyA | |
| MW, pI | 45 kDa, 5.475 |
| Gene length, protein length | 1245 bp, 415 aa |
| Immediate neighbours | upp, ywlG |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, essential genes, phosphoproteins, most abundant proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU36900
Phenotypes of a mutant
essential PubMed
Database entries
- BsubCyc: BSU36900
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine (according to Swiss-Prot)
- Protein family: SHMT family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- BsubCyc: BSU36900
- Structure: 2VGU (complex with L-serine, Geobacillus stearothermophilus), 2VI8 (Geobacillus stearothermophilus)
- UniProt: P39148
- KEGG entry: [3]
- E.C. number: 2.1.2.1
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- T-box: RNA switch, transcriptional antitermination PubMed
- PurR: transcription repression (molecular inducer: PRPP) PubMed
- Additional information:
- belongs to the 100 most abundant proteins PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
