atpE

168

ATP synthase, part of the Fo complex (subunit c)

Locus: BSU_36860

Molecular weight: 6.96 kDa

Isoelectric point: 6.43

Protein length: 70 aa

Gene length: 213 bp

Function: ATP synthesis

Product: ATP synthase (subunit c)

Essential: no

Synonyms: atpE

Genomic Context

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List of homologs in different organisms, belongs to COG0636 (Galperin et al., 2021)

Gene

Coordinates: 3,786,620  3,786,832

The protein

Catalyzed reaction/ biological activity

• ATP synthesis see a video

Protein family

• ATPase C chain family (single member, according to UniProt)

Structure

• 1WU0 (PDB) (from Bacillus sp., 73% identity)
• P37815 (AlphaFold)

Effectors of protein activity

• ATPase activity is inhibited upon binding of Mg-ADP to AtpD PubMed

Localization

• membrane PubMed

Expression and Regulation

Operons

• Genes: atpI-atpB-atpE-atpF-atpH-atpA-atpG-atpD-atpC

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed
  • the mRNA is processed between atpI and atpB by RNase Y, this requires the RicA-RicF-RicT complex PubMed

  Regulatory mechanism

  • stringent response: negative regulation, in stringent response

Biological materials

Mutant

• BKE36860 (atpE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAAAAGTTCCTCCTTT,  downstream forward: _UP4_TAAGCATAAAAGCCTTATAT
• BKK36860 (atpE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGAAAAAGTTCCTCCTTT,  downstream forward: _UP4_TAAGCATAAAAGCCTTATAT

References

Reviews

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Original Publications

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