rapD

168

response regulator aspartate phosphatase, controls ComA activity

Locus: BSU_36380

Molecular weight: 41.98 kDa

Isoelectric point: 7.69

Protein length: 354 aa

Gene length: 1065 bp

Function: control of ComA-dependent gene expression

Product: response regulator aspartate phosphatase

Essential: no

Synonyms: rapD, ywpA

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 3,744,349  3,745,413

The protein

Catalyzed reaction/ biological activity

• control of ComA-dependent gene expression PubMed

Protein family

• RAP family (according to UniProt)

Domains

• six tetratrichopeptide repeats (according to UniProt)

Structure

• 4I9E (PDB) (RapF, 26% identity) PubMed
• P94583 (AlphaFold)

Expression and Regulation

Operons

• Genes: rapD

  Description: PubMed

  Regulation

  • repressed by RghR PubMed

  Expression

  • expression is heterogeneous PubMed

  Regulatory mechanism

  • RghR: repression, PubMed, in rghR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigM: sigma factor, PubMed, in sigM regulon
  • SigX: sigma factor, PubMed, in sigX regulon

Biological materials

Mutant

• MGNA-A079 (rapD::erm), available at the NBRP B. subtilis, Japan
• BKE36380 (rapD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCCTACCTCTTTGCT,  downstream forward: _UP4_TGATTGAAAAACGCCCATTT
• BKK36380 (rapD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTTCCTACCTCTTTGCT,  downstream forward: _UP4_TGATTGAAAAACGCCCATTT

References

Reviews

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Original Publications

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