CapE

• Description: stimulates poly-gamma-glutamate production in the presence of zinc, also involved in extra-chromosomal DNA maintenance
  
  

Gene name	capE
Synonyms	ywtC, pgsE, edmS
Essential	no
Product	unknown
Function	capsule synthesis
Gene expression levels in SubtiExpress: capE
MW, pI	6 kDa, 6.487
Gene length, protein length	165 bp, 55 aa
Immediate neighbours	pgdS, capA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

capsule biosynthesis and degradation, membrane proteins

This gene is a member of the following regulons

DegU regulon

The gene

Basic information

• Locus tag: BSU35870

Database entries

• BsubCyc: BSU35870

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • stimulates poly-gamma-glutamate production in the presence of zinc PubMed
  • also involved in extra-chromosomal DNA maintenance PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: N-terminal membrane-anchoring domain and a C-terminal assembly accelerator-like structure PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane PubMed

Database entries

• BsubCyc: BSU35870

• Structure:

• UniProt: P96739

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: capB-capC-capA-capE PubMed

• Expression browser: capE PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism: activated by DegU-P PubMed

• Additional information: The operon is not expressed in the lab strain 168 due to lack of expression of DegQ resulting in inactivity of DegS and DegU PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Thomas Candela, Agnès Fouet
Poly-gamma-glutamate in bacteria.
Mol Microbiol: 2006, 60(5);1091-8
[PubMed:16689787] [WorldCat.org] [DOI] (P p)