psdB

168

ABC transporter (permease) for the export of lipid II-binding lantibiotics, such as nisin and gallidermin

Locus: BSU_34690

Molecular weight: 73.22 kDa

Isoelectric point: 9.8

Protein length: 646 aa

Gene length: 1941 bp

Function: export of toxic peptides

Product: ABC transporter (permease)

Essential: no

Synonyms: psdB, yvcS

Genomic Context

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List of homologs in different organisms, belongs to COG0577 (Galperin et al., 2021)

Gene

Coordinates: 3,563,581  3,565,521

The protein

Protein family

• ABC-4 integral membrane protein family (according to UniProt)

Structure

• O06981 (AlphaFold)

Paralogous protein(s)

• YxdM

Localization

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: psdR-psdS-psdA-psdB

  Description: PubMed

  Regulation

  • ''psdA'': induced by nisin, gallidermin (PsdR) PubMed

  Regulatory mechanism

  • PsdR: activation, PubMed, in psdR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

• Genes: psdA-psdB

  Description: PubMed

  Regulation

  • ''psdA'': induced by nisin, gallidermin (PsdR) PubMed

Biological materials

Mutant

• MGNA-B634 (yvcS::erm), available at the NBRP B. subtilis, Japan
• BKE34690 (psdB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCGTTGCAGATTCCCAAGAA,  downstream forward: _UP4_TAATATGAAATCCGGTCTGT
• BKK34690 (psdB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CCGTTGCAGATTCCCAAGAA,  downstream forward: _UP4_TAATATGAAATCCGGTCTGT

References

Reviews

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Original Publications

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