sdpI

168

immunity protein, protection against SdpC

Locus: BSU_33780

Molecular weight: 23.15 kDa

Isoelectric point: 9.61

Protein length: 207 aa

Gene length: 624 bp

Function: protection against SdpC

Product: immunity protein

Essential: no

E.C.: null

Synonyms: sdpI, yvaZ

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG5658 (Galperin et al., 2021)

Gene

Coordinates: 3,466,434  3,467,057

The protein

Structure

• O32241 (AlphaFold)

Effectors of protein activity

• in the presence of extracellular SdpC, SdpI binds and sequesters SdpR , this results in induction of the ''sdpR-sdpI'' operon PubMed

Paralogous protein(s)

• YfhL, YbgB

Localization

• membrane (according to UniProt)

Expression and Regulation

Operons

• Genes: sdpR-sdpI

  Description: PubMed

  Regulation

  • induced by extracellular SdpC (SdpR) PubMed

  Regulatory mechanism

  • AbrB: repression, PubMed, in abrB regulon
  • SdpR: repression, PubMed, in sdpR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

Biological materials

Mutant

• MGNA-A454 (yvaZ::erm), available at the NBRP B. subtilis, Japan
• BKE33780 (sdpI::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATTATGGAAATTATATTTT,  downstream forward: _UP4_TGAAAAAGTGTCTTGCGGAG
• BKK33780 (sdpI::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_AATTATGGAAATTATATTTT,  downstream forward: _UP4_TGAAAAAGTGTCTTGCGGAG

References

Reviews

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Original Publications

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