SdpA

• Description: required for SdpC toxin maturation
  
  

Gene name	sdpA
Synonyms	yvaW
Essential	no
Product	unknown
Function	maturation of the SdpC toxin
Gene expression levels in SubtiExpress: sdpA
MW, pI	18 kDa, 9.766
Gene length, protein length	474 bp, 158 aa
Immediate neighbours	yvaV, sdpB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

AbrB regulon, Rok regulon, Spo0A regulon

The gene

Basic information

• Locus tag: BSU33750

Database entries

• BsubCyc: BSU33750

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm PubMed

Database entries

• BsubCyc: BSU33750

• Structure:

• UniProt: O34889

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: sdpA-sdpB-sdpC PubMed

• Expression browser: sdpA PubMed

• Sigma factor:

• Regulation: repressed by glucose (8-fold) PubMed
  • expressed under conditions that trigger sporulation (Spo0A) PubMed
  • repressed by Rok PubMed
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism:
  • Spo0A: transcription activation PubMed
  • Rok: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:
  • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol Rev: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)