menD

168

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase

Locus: BSU_30820

Molecular weight: 63.92 kDa

Isoelectric point: 5.66

Protein length: 580 aa

Gene length: 1743 bp

Function: biosynthesis of menaquinone

Product: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase / 2-oxoglutarate decarboxylase

Essential: yes

E.C.: 2.2.1.9

Synonyms: menD

Genomic Context

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List of homologs in different organisms, belongs to COG1165 (Galperin et al., 2021)

Gene

Coordinates: 3,150,563 → 3,152,305

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 2-oxoglutarate + H⁺ + isochorismate --> 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO₂ (according to UniProt)

Protein family

• TPP enzyme family (according to UniProt)

Cofactors

• thiamine pyrophosphate, divalent metal ion such as Mn(2+)) PubMed

Structure

• 2X7J (PDB) PubMed
• P23970 (AlphaFold)

Expression and Regulation

Operons

• Genes: menF-menD-ytxM-menB-menE-menC

  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

  Additional information

  • A ncRNA is predicted between 'mntA' and 'menC' PubMed

References

Reviews

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Original Publications

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