ccrZ

168

activator of DnaA-dependent initiation of DNA replication

Locus: BSU_29920

Molecular weight: 30.64 kDa

Isoelectric point: 5.81

Protein length: 204 aa

Gene length: 615 bp

Function: control of DNA replication

Product: activator of DnaA-dependent initiation of DNA replication

Essential: no

Synonyms: ytmP

Genomic Context

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List of homologs in different organisms, belongs to COG0510 (Galperin et al., 2021)

Gene

Coordinates: 3,060,674  3,061,288

Phenotypes of a mutant

• sensitive to DNA damage PubMed

The protein

Protein family

• aminoglycoside phosphotransferase family (with YcbJ, according to UniProt)

Structure

• 7S3L (PDB) PubMed
• 4R77 (PDB) (from Streptococcus pneumoniae, 27% identity) PubMed
• C0SPC1 (AlphaFold)

Expression and Regulation

Operons

• Genes: ccrZ

  Description: PubMed

Biological materials

Mutant

• MGNA-A434 (ytmP::erm), available at the NBRP B. subtilis, Japan
• BKE29920 (ccrZ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCGTTTTGTCCAAACCA,  downstream forward: _UP4_CTCATGAAACGAATTGTTGA
• BKK29920 (ccrZ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCCGTTTTGTCCAAACCA,  downstream forward: _UP4_CTCATGAAACGAATTGTTGA

References

Research papers

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