dnaB

168

initiation of chromosome replication/ membrane attachment protein, part of the replisome

Locus: BSU_28990

Molecular weight: 54.72 kDa

Isoelectric point: 5.28

Protein length: 472 aa

Gene length: 1419 bp

Function: DNA replication

Product: helicase loader, initiation of chromosome replication/ membrane attachment protein

Essential: yes

Synonyms: dnaB

Genomic Context

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List of homologs in different organisms, belongs to COG3611 (Galperin et al., 2021)

Gene

Coordinates: 2,964,148  2,965,566

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• binds double-stranded DNA and co-loads the replicative helicase PubMed

Structure

• 5WTN (PDB) (from Geobacillus stearothermophilus, 47% identity, N-terminal domain, aa 1 - 300) PubMed
• P07908 (AlphaFold)

Localization

• Membrane-proximal (Spotty) PubMed
• forms foci, close to oriC PubMed

Expression and Regulation

Operons

• Genes: dnaB-dnaI-ytxB-ytxC-thrS

  Description: PubMed

References

Reviews

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Original Publications

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