spoIIP

spoIIP
168

cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall and for ribosome translocation to the forespore

Locus
BSU_25530
Molecular weight
44.39 kDa
Isoelectric point
6.85
Protein length
Gene length
Product
cell wall hydrolase
Essential
no
Synonyms
spoIIP

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5819 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,633,237 → 2,634,442
The protein
Catalyzed reaction/ biological activity
removes the stem peptides from the cell wall and cleaves the cross-links between them PubMed
required for proper localization of SpoIIQ (together with SpoIID) PubMed
Structure
Effectors of protein activity
activity is stimulated by interaction with SpoIID PubMed
cell membrane PubMed
the complex of SpoIID, SpoIIM, and SpoIIP localizes at the leading edge of the mother cell engulfing membrane and is essential and rate limiting for membrane migration PubMed
localization of SpoIIP to the leading edge depends on peptidoglycan synthesis at the leading edge of the engulfing membrane PubMed
localization of the SpoIID-SpoIIM-SpoIIP complex to the septal membrane depends on SpoIIB PubMed
Expression and Regulation
Operons
Description
Regulation
expressed early during sporulation (SigE,SigF) PubMed
Sigma factors
SigE: sigma factor, PubMed, in sigE regulon
SigF: sigma factor, PubMed, in sigF regulon
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spoIIPyqxA

2025-06-05 00:31:42

Jstuelk

90

5495415a64ffbddb53f9af5648665545cdd70acf

042FDB8BC878C6C4356A9F4C7D3A4887CDAF33A3

Genes
Description
Regulation
expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed
Regulatory mechanism
SpoVT: repression, PubMed, in spoVT regulon
Sigma factors
SigF: sigma factor, PubMed, in sigF regulon
SigG: sigma factor, PubMed, in sigG regulon
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gprspoIIP

2025-06-02 00:08:21

Jstuelk

103

76a8c0a73904216fb84776d2606465c8bd587731

DC8A669EDBB0F070BE63D7364C4DD18943FA2867

Additional information
translation is likely to require Efp due to the presence of several consecutive proline residues PubMed
Biological materials
Mutant
BKE25530 (ΔspoIIP::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATTGAATCCCTCCAGCGCT,  downstream forward: _UP4_AAACAATAAGAAATAGGTGG
BKK25530 (ΔspoIIP::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATTGAATCCCTCCAGCGCT,  downstream forward: _UP4_AAACAATAAGAAATAGGTGG
References
Reviews
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Original Publications
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C9817A54C8E72193280E393D7BD3375BD1751738

Page visits: 3669

Time of last update: 2025-06-07 06:48:06

Author of last update: Jstuelk