spoIIP
168
cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall and for ribosome translocation to the forespore
Locus
BSU_25530
Molecular weight
44.39 kDa
Isoelectric point
6.85
Product
cell wall hydrolase
Essential
no
Synonyms
spoIIP
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG5819 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,633,237 → 2,634,442
The protein
Catalyzed reaction/ biological activity
removes the stem peptides from the cell wall and cleaves the cross-links between them PubMed
Structure
Effectors of protein activity
cell membrane PubMed
the complex of SpoIID, SpoIIM, and SpoIIP localizes at the leading edge of the mother cell engulfing membrane and is essential and rate limiting for membrane migration PubMed
localization of SpoIIP to the leading edge depends on peptidoglycan synthesis at the leading edge of the engulfing membrane PubMed
Expression and Regulation
Operons
Additional information
translation is likely to require Efp due to the presence of several consecutive proline residues PubMed
Biological materials
Mutant
References
Reviews
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Original Publications
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Time of last update: 2025-06-07 06:48:06
Author of last update: Jstuelk