aroC

168

3-dehydroquinate dehydratase

Locus: BSU_23080

Molecular weight: 27.98 kDa

Isoelectric point: 4.9

Protein length: 255 aa

Gene length: 768 bp

Function: biosynthesis of aromatic amino acids

Product: 3-dehydroquinate dehydratase

Essential: no

E.C.: 4.2.1.10

Synonyms: aroC

Genomic Context

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Categories containing this gene/protein

Metabolism, Amino acid/ nitrogen metabolism, Biosynthesis/ acquisition of amino acids, Biosynthesis/ acquisition of aromatic amino acids

List of homologs in different organisms, belongs to COG0710 (Galperin et al., 2021)

Gene

Coordinates: 2,412,706  2,413,473

The protein

Catalyzed reaction/ biological activity

3-dehydroquinate --> 3-dehydroshikimate + H₂O (according to UniProt)

Protein family

type-I 3-dehydroquinase family (single member, according to UniProt)

Structure

1GQN (PDB) (from Salmonella typhi, 55% identity, 70% similarity) PubMed
P35146 (AlphaFold)

Expression and Regulation

Operons

Genes: aroC

Description: PubMed

Biological materials

Mutant

BKE23080 (aroC::erm  trpC2) available at BGSC and in Jörg Stülke's lab,  PubMed, upstream reverse: _UP1_CACTCGTCTCAAATCCTTTC,  downstream forward: _UP4_TAGAACAATAAAAAAACTCA
BKK23080 (aroC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CACTCGTCTCAAATCCTTTC,  downstream forward: _UP4_TAGAACAATAAAAAAACTCA

References

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