Difference between revisions of "OdhA"
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=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU19370&redirect=T BSU19370] | ||
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/odhAB.html] | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/odhAB.html] | ||
| Line 95: | Line 96: | ||
=== Database entries === | === Database entries === | ||
| + | * '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU19370&redirect=T BSU19370] | ||
* '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2jgd 2JGD] (from ''Escherichia coli'', 38% identity, 55% similarity) {{PubMed|17367808}} | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2jgd 2JGD] (from ''Escherichia coli'', 38% identity, 55% similarity) {{PubMed|17367808}} | ||
Revision as of 13:55, 2 April 2014
- Description: 2-oxoglutarate dehydrogenase (E1 subunit)
| Gene name | odhA |
| Synonyms | citK |
| Essential | no |
| Product | 2-oxoglutarate dehydrogenase (E1 subunit) |
| Function | TCA cycle |
| Gene expression levels in SubtiExpress: odhA | |
| Interactions involving this protein in SubtInteract: OdhA | |
| Metabolic function and regulation of this protein in SubtiPathways: odhA | |
| MW, pI | 105 kDa, 5.871 |
| Gene length, protein length | 2823 bp, 941 aa |
| Immediate neighbours | odhB, yojO |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
carbon core metabolism, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU19370
Phenotypes of a mutant
Database entries
- BsubCyc: BSU19370
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 (according to Swiss-Prot)
- Protein family: 2-oxoacid dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- phosphorylated on Arg-66 and Arg-621 PubMed
- Effectors of protein activity:
Database entries
- BsubCyc: BSU19370
- UniProt: P23129
- KEGG entry: [3]
- E.C. number: 1.2.4.2
Additional information
- extensive information on the structure and enzymatic properties of 2-oxoglutarate dehydrogenase can be found at Proteopedia
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- GP671 (spc), GP684 (cat), GP1274 (cat) available in Jörg Stülke's lab
- GP1276 (odhA-odhB::cat), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
K F Sheu, J P Blass
The alpha-ketoglutarate dehydrogenase complex.
Ann N Y Acad Sci: 1999, 893;61-78
[PubMed:10672230]
[WorldCat.org]
[DOI]
(P p)
Original publications
