phrK

168

response regulator aspartate phosphatase (RapK) regulator, controls ComA activity

Locus: BSU_18920

Molecular weight: 3.98 kDa

Isoelectric point: 8.16

Protein length: 40 aa

Gene length: 123 bp

Function: control of ComA activity

Product: phosphatase (RapK) regulator

Essential: no

Synonyms: phrK

Genomic Context

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Categories containing this gene/protein

Information processing, Genetics, Genetic competence

Information processing, Regulation of gene expression, Transcription factors and their control, Control of two-component response regulators, Control of response regulators/ other

Information processing, Regulation of gene expression, Quorum sensing

Lifestyles, Exponential and early post-exponential lifestyles, Genetic competence

Groups of genes, Short peptides

List of homologs in different organisms

This gene is a member of the following regulons

AbrB regulon, PhoP regulon, SigH regulon

Gene

Coordinates: 2,063,262  2,063,384

The protein

Catalyzed reaction/ biological activity

inhibits RapK activity PubMed

Protein family

phr family (according to UniProt)

Structure

O31840 (AlphaFold)

Expression and Regulation

Operons

Genes: rapK-phrK

Description: PubMed

Regulation

induced under conditions of phosphate limitation (PhoP) PubMed

Regulatory mechanism

PhoP: activation, PubMed, in phoP regulon
AbrB: repression, PubMed, in abrB regulon

Sigma factors

SigH: sigma factor, PubMed, in sigH regulon

Biological materials

Mutant

BKE18920 (phrK::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATAAGATTCCCTCCAC,  downstream forward: _UP4_TAAAAAAGGTTGATTAATTA
BKK18920 (phrK::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATAAGATTCCCTCCAC,  downstream forward: _UP4_TAAAAAAGGTTGATTAATTA

References

Reviews

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Original Publications

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