phrK

168

response regulator aspartate phosphatase (RapK) regulator, controls ComA activity

Locus: BSU_18920

Molecular weight: 3.98 kDa

Isoelectric point: 8.16

Protein length: 40 aa

Gene length: 123 bp

Function: control of ComA activity

Product: phosphatase (RapK) regulator

Essential: no

Synonyms: phrK

Genomic Context

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List of homologs in different organisms

Gene

Coordinates: 2,063,262  2,063,384

The protein

Catalyzed reaction/ biological activity

• inhibits RapK activity PubMed

Protein family

• phr family (according to UniProt)

Structure

• O31840 (AlphaFold)

Expression and Regulation

Operons

• Genes: rapK-phrK

  Description: PubMed

  Regulation

  • induced under conditions of phosphate limitation (PhoP) PubMed

  Regulatory mechanism

  • PhoP: activation, PubMed, in phoP regulon
  • AbrB: repression, PubMed, in abrB regulon

  Sigma factors

  • SigH: sigma factor, PubMed, in sigH regulon

Biological materials

Mutant

• BKE18920 (phrK::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATAAGATTCCCTCCAC,  downstream forward: _UP4_TAAAAAAGGTTGATTAATTA
• BKK18920 (phrK::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TTTCATAAGATTCCCTCCAC,  downstream forward: _UP4_TAAAAAAGGTTGATTAATTA

References

Reviews

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Original Publications

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