penP

168

beta-lactamase

Locus: BSU_18800

Molecular weight: 33.29 kDa

Isoelectric point: 9.21

Protein length: 306 aa

Gene length: 921 bp

Function: resistance to beta-lactam antibiotics

Product: beta-lactamase

Essential: no

E.C.: 3.5.2.6

Synonyms: penP

Genomic Context

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Categories containing this gene/protein

Lifestyles, Coping with stress, Resistance against toxins/ antibiotics

Groups of genes, Secreted proteins

List of homologs in different organisms, belongs to COG2367 (Galperin et al., 2021)

Gene

Coordinates: 2,048,533  2,049,453

The protein

Catalyzed reaction/ biological activity

β-lactam + H₂O --> substituted β-amino acid (according to UniProt)

Protein family

beta-lactamase family (according to UniProt)
class-A beta-lactamase family (single member, according to UniProt)

Structure

6NI1 (PDB)
P39824 (AlphaFold)

Localization

extracellular (signal peptide) PubMed

Expression and Regulation

Operons

Genes: penP

Description: PubMed

Biological materials

Mutant

BKE18800 (penP::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA,  downstream forward: _UP4_TAATATGTTTAGCCTTTTGC
BKK18800 (penP::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCAGGCCTCCTCATTCAA,  downstream forward: _UP4_TAATATGTTTAGCCTTTTGC

References

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