pdhI

pdhI
168

inhibitor of pyruvate dehydrogenase

Locus
BSU_18060
Molecular weight
10.69 kDa
Isoelectric point
3.67
Protein length
Gene length
Function
control of pyruvate dehydrogenase activity
Product
inhibitor of pyruvate dehydrogenase
Essential
no
E.C.
null
Synonyms
yneR

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG4841 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,931,545  1,931,832
The protein
Catalyzed reaction/ biological activity
binds to PdhA and PdhB to inhibit pyruvate dehydrogenase activity PubMed
Protein family
HesB/IscA family (with SufA, according to UniProt)
Structure
Expression and Regulation
Operons
Genes
Description
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plsYpdhI

2025-07-05 13:57:55

Jstuelk

115

17bd1a64270d52da5e9c32beab0ad8ee03999451

90AF7F64584B2502F3FFC532A6C62C68E9CE7824

Biological materials
Mutant
GP3317 (ΔpdhI::cat), available in Jörg Stülke's lab
BKE18060 (pdhI::erm  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATAACAGAACACCCCTTTG,  downstream forward: _UP4_TAAAAAAGAACGCACTTCAT
BKK18060 (pdhI::kan  trpC2) available at BGSCPubMed, upstream reverse: _UP1_CATAACAGAACACCCCTTTG,  downstream forward: _UP4_TAAAAAAGAACGCACTTCAT
Expression vectors
pGP3580 (N-terminal 6xHis-tag, purification from E. coli, in pWH844), available in Jörg Stülke's lab
pGP3588: expression of pdhI by pBQ200 in B. subtilis, available in Jörg Stülke's lab
References
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5959516D55C9EDBFC46F28C8248D374832895740

Page visits: 2765

Time of last update: 2025-07-10 18:04:24

Author of last update: Jstuelk