mraZ

168

transcription repressor of the mraZ-rsmH-ftsL-pbpB operon

Locus: BSU_15130

Molecular weight: 16.43 kDa

Isoelectric point: 4.97

Protein length: 143 aa

Gene length: 432 bp

Function: control of cell division gene expression

Product: transcription repressor of the mraZ-rsmH-ftsL-pbpB operon

Essential: no

E.C.: null

Synonyms: mraZ, yllB

Genomic Context

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List of homologs in different organisms, belongs to COG2001 (Galperin et al., 2021)

Gene

Coordinates: 1,580,121  1,580,552

Phenotypes of a mutant

• overexpression results in lethal filamentation (due to repression of the own operon, can be rescued by constitutive expression of FtsL) PubMed

The protein

Protein family

• mraZ family (single member, according to UniProt)

Domains

• 2 SpoVT-AbrB domains (aa 7-47, aa 76-119) (according to UniProt)

Structure

• 1N0G (PDB) (the homolog from Mycoplasma pneumoniae) PubMed
• P55343 (AlphaFold)

Localization

• nucleoid (heterogeneous) PubMed

Expression and Regulation

Operons

• Genes: mraZ-rsmH-ftsL-pbpB

  Description: PubMed

  Regulation

  • constitutively expressed PubMed

Biological materials

Mutant

• MGNA-B129 (yllB::erm), available at the NBRP B. subtilis, Japan
• 1A817 ( mraZ::erm), PubMed, available at BGSC
• BKE15130 (mraZ::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCTCTTGCCCCACTT,  downstream forward: _UP4_TAATGATTCTTCGTGTATAA
• BKK15130 (mraZ::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGATCTCTTGCCCCACTT,  downstream forward: _UP4_TAATGATTCTTCGTGTATAA

References

Reviews

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Original Publications

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