coaD

168

phosphopantetheine adenylyltransferase

Locus: BSU_15020

Molecular weight: 18.04 kDa

Isoelectric point: 5.65

Protein length: 161 aa

Gene length: 486 bp

Function: biosynthesis of coenzyme A

Product: phosphopantetheine adenylyltransferase

Essential: yes

E.C.: 2.7.7.3

Synonyms: ylbI

Genomic Context

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List of homologs in different organisms, belongs to COG0669 (Galperin et al., 2021)

Gene

Coordinates: 1,570,078  1,570,563

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + phosphopantetheine + H⁺ --> 3'-dephospho-CoA + diphosphate PubMed

Protein family

• bacterial coaD family (single member, according to UniProt)

Structure

• 1O6B (PDB) (complex with ADP)
• O34797 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: ricF-ylbG-ylbH-coaD

  Description: PubMed

• Genes: ylbH-coaD

  Description: PubMed

Biological materials

Mutant

• MGNA-B360 (ylbI::erm), available at the NBRP B. subtilis, Japan

References

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