ctaC

168

cytochrome-c oxidase (caa₃) (subunit II)

Locus: BSU_14890

Molecular weight: 39.94 kDa

Isoelectric point: 8.64

Protein length: 356 aa

Gene length: 1071 bp

Function: respiration

Product: cytochrome-c oxidase (subunit II)

Essential: no

E.C.: 1.9.3.1

Synonyms: ctaC

Genomic Context

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List of homologs in different organisms, belongs to COG2857 (Galperin et al., 2021)

Gene

Coordinates: 1,560,466  1,561,536

The protein

Catalyzed reaction/ biological activity

• 4 [Fe(II)cytochrome c] + 4 H⁺ + O₂ --> 4 [Fe(III)cytochrome c] + 2 H₂O (according to UniProt)

Protein family

• cytochrome c oxidase subunit 2 family (with QoxA, according to UniProt)

Domains

• Cytochrome c domain (aa 258-356) (according to UniProt)

Cofactors

• Cu(A) PubMed

Structure

• 2YEV (PDB) (from Thermus thermophilus, 35% identity) PubMed
• P24011 (AlphaFold)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: ctaB-ctaC-ctaD-ctaE-ctaF-ctaG

  Description: PubMed

  Regulation

  • expressed under anaerobic conditions (ResD) PubMed

  Regulatory mechanism

  • ResD: activation, PubMed, in resD regulon
  • Abh: repression, synergistic repression with AbrB, in abh regulon
  • CcpA: repression, in ccpA regulon
  • AbrB: repression, synergistic repression with Abh, in abrB regulon

Biological materials

Mutant

• BKE14890 (ctaC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCACCCAACCCCTTTT,  downstream forward: _UP4_TAGGGAAGAAAGGGAGATAT
• BKK14890 (ctaC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCACCCAACCCCTTTT,  downstream forward: _UP4_TAGGGAAGAAAGGGAGATAT

References

Reviews

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Original Publications

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