spo0E

168

Spo0A-P phosphatase, control of the phosphorelay

Locus: BSU_13640

Molecular weight: 9.65 kDa

Isoelectric point: 6.48

Protein length: 85 aa

Gene length: 258 bp

Function: initiation of sporulation

Product: Spo0A-P phosphatase

Essential: no

Synonyms: spo0E

Genomic Context

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List of homologs in different organisms, belongs to COG5804 (Galperin et al., 2021)

Gene

Coordinates: 1,430,684  1,430,941

The protein

Protein family

• spo0E family (with ynzd and YisI, according to UniProt)

Structure

• P05043 (AlphaFold)

Paralogous protein(s)

• YnzD

Expression and Regulation

Operons

• Genes: spo0E

  Description: PubMed

  Regulation

  • induced under stress conditions (SigB) PubMed

  Regulatory mechanism

  • AbrB: repression, PubMed, in abrB regulon
  • Rok: repression, of the SigB-dependent promoter PubMed, in rok regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon
  • SigB: sigma factor, PubMed, in sigB regulon

  Additional information

  • Spo0E is degraded by FtsH

Biological materials

Mutant

• BKE13640 (spo0E::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCACTTCACCCCTCGCC,  downstream forward: _UP4_TAGCGGCCTATCAGATGCAT
• BKK13640 (spo0E::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTCACTTCACCCCTCGCC,  downstream forward: _UP4_TAGCGGCCTATCAGATGCAT

Labs working on this gene/protein

• Tony Wilkinson, York University, U.K. homepage

References

Reviews

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Original Publications

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