ykcC

168

lipoteichoic acid glycosyltransferase, generation of C₅₅-P-Glc

Locus: BSU_12890

Molecular weight: 37.22 kDa

Isoelectric point: 8.01

Protein length: 323 aa

Gene length: 972 bp

Function: glycosylation of teichoic acids

Product: glycosyltransferase

Essential: no

Synonyms: ykcC

Genomic Context

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List of homologs in different organisms, belongs to COG0463 (Galperin et al., 2021)

Gene

Coordinates: 1,356,447 → 1,357,418

The protein

Protein family

• glycosyltransferase 2 family (according to UniProt)

Structure

• 5EKP (PDB) (from Synechocystis sp., 47% identity) PubMed
• O34319 (AlphaFold)

Paralogous protein(s)

• CsbB
• YkoT, (39%)

Localization

• cell membrane (heterogeneous) PubMed

Expression and Regulation

Operons

• Genes: ykcB-ykcC

  Description: PubMed

  Regulatory mechanism

  • YclJ: activation, PubMed, in yclJ regulon
  • YrkP: activation, PubMed, in yrkP regulon

Biological materials

Mutant

• MGNA-A739 (ykcC::erm), available at the NBRP B. subtilis, Japan
• BKE12890 (ΔykcC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATGTCTGCTCATGTTTTTGC,  downstream forward: _UP4_TAACCTCAAACCCCCTGTCC
• BKK12890 (ΔykcC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_ATGTCTGCTCATGTTTTTGC,  downstream forward: _UP4_TAACCTCAAACCCCCTGTCC

References

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