mutT
168
antimutator protein, has RNA pyrophosphohydrolase activity
Locus
BSU_04330
Molecular weight
16.26 kDa
Isoelectric point
8.59
Function
DNA repair, protection against oxidative stress
Product
antimutator protein
Essential
no
Synonyms
mutT
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG1051 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
488,314 488,763
The protein
Catalyzed reaction/ biological activity
8-oxo-dGTP + H2O --> 8-oxo-dGMP + diphosphate + H+ (according to UniProt)
Protein family
Nudix hydrolase (according to UniProt)
Nudix hydrolase domain (aa 1-123) (according to UniProt)
Mn2+ PubMed
Structure
1VC8 (PDB) (N-terminal 100 amino acids of Ap6A hydrolase from Thermus thermophilus, 40% identity)
Biological materials
Mutant
MGNA-C093 (mutT::erm), available at the NBRP B. subtilis, Japan
JH642 and its derivatives: natural deletion of the 18 kb ydzA-mntH region encompassing the genes ydzA-topB-ydaJ-ydaK-ydaL-ydaM-ydaN-kimA-mutT-ydaP-ydzK-mntH PubMed
References
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Time of last update: 2025-05-15 20:46:19
Author of last update: Jstuelk