tlpC

168

membrane-bound chemotaxis receptor, methyl-accepting chemotaxis protein

Locus: BSU_03440

Molecular weight: 61.62 kDa

Isoelectric point: 4.93

Protein length: 573 aa

Gene length: 1722 bp

Function: control of chemotaxis

Product: methyl-accepting chemotaxis protein

Essential: no

Synonyms: tlpC

Genomic Context

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List of homologs in different organisms, belongs to COG3290 (Galperin et al., 2021)

Gene

Coordinates: 372,771  374,492

The protein

Domains

• HAMP domain (aa 194-246) (according to UniProt)
• Methyl-accepting transducer domain (aa 280-544) (according to UniProt)

Structure

• 6S1K (PDB) (from E. coli, corresponds to aa 151 ... 498, 28.6% identity) PubMed
• P39209 (AlphaFold)

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: tlpC

  Description: PubMed

  Sigma factors

  • SigD: sigma factor, PubMed, in sigD regulon

  Additional information

  • in minimal medium,TlpC is present with 5,400 /- 1700 molecules per cell PubMed

Biological materials

Mutant

• BKE03440 (tlpC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATTCCTCCCTTTACGA,  downstream forward: _UP4_TGATGACTTACTATCATTAT
• BKK03440 (tlpC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAATTCCTCCCTTTACGA,  downstream forward: _UP4_TGATGACTTACTATCATTAT

References

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