Difference between revisions of "PbpH"
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| − | * '''Description:''' [[penicillin-binding protein]] H <br/><br/> | + | * '''Description:''' class B [[penicillin-binding protein]] H <br/><br/> |
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
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** part of the [[cell wall biosynthetic complex]] {{PubMed|21636744,21636745}} | ** part of the [[cell wall biosynthetic complex]] {{PubMed|21636744,21636745}} | ||
| − | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | + | * '''[[Localization]]:''' |
| + | ** cell membrane (according to Swiss-Prot) | ||
=== Database entries === | === Database entries === | ||
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=References= | =References= | ||
| − | <pubmed> 12896990 20525796 21636744,21636745 20817675 23199363</pubmed> | + | <pubmed> 12896990 20525796 21636744,21636745 20817675 23199363 23895585 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:09, 5 March 2014
- Description: class B penicillin-binding protein H
| Gene name | pbpH |
| Synonyms | ykuA |
| Essential | no |
| Product | penicillin-binding protein H |
| Function | formation of a rod-shaped peptidoglycan cell wall |
| Gene expression levels in SubtiExpress: pbpH | |
| MW, pI | 76 kDa, 8.888 |
| Gene length, protein length | 2055 bp, 685 aa |
| Immediate neighbours | ykwD, kinA |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
cell wall synthesis, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13980
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: transpeptidase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Interactions:
- part of the cell wall biosynthetic complex PubMed
- Localization:
- cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: Q796K8
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Marta Carolina Afonso Lages, Katrin Beilharz, Danae Morales Angeles, Jan-Willem Veening, Dirk-Jan Scheffers
The localization of key Bacillus subtilis penicillin binding proteins during cell growth is determined by substrate availability.
Environ Microbiol: 2013, 15(12);3272-81
[PubMed:23895585]
[WorldCat.org]
[DOI]
(I p)
Letal I Salzberg, Leagh Powell, Karsten Hokamp, Eric Botella, David Noone, Kevin M Devine
The WalRK (YycFG) and σ(I) RsgI regulators cooperate to control CwlO and LytE expression in exponentially growing and stressed Bacillus subtilis cells.
Mol Microbiol: 2013, 87(1);180-95
[PubMed:23199363]
[WorldCat.org]
[DOI]
(I p)
Ethan C Garner, Remi Bernard, Wenqin Wang, Xiaowei Zhuang, David Z Rudner, Tim Mitchison
Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis.
Science: 2011, 333(6039);222-5
[PubMed:21636745]
[WorldCat.org]
[DOI]
(I p)
Julia Domínguez-Escobar, Arnaud Chastanet, Alvaro H Crevenna, Vincent Fromion, Roland Wedlich-Söldner, Rut Carballido-López
Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria.
Science: 2011, 333(6039);225-8
[PubMed:21636744]
[WorldCat.org]
[DOI]
(I p)
Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675]
[WorldCat.org]
[DOI]
(I p)
Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796]
[WorldCat.org]
[DOI]
(I p)
Yuping Wei, Teresa Havasy, Derrell C McPherson, David L Popham
Rod shape determination by the Bacillus subtilis class B penicillin-binding proteins encoded by pbpA and pbpH.
J Bacteriol: 2003, 185(16);4717-26
[PubMed:12896990]
[WorldCat.org]
[DOI]
(P p)
