Difference between revisions of "FtsX"
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| − | * '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/> | + | * '''Description:''' [[ABC transporter]] (membrane protein) ([[FtsE]]-[[FtsX]]), required for [[CwlO]] activity (cell elongation) and for proper activation of [[Spo0A]] and initiation of [[sporulation]] <br/><br/> |
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | * a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23855774}} | + | * a ''[[ftsX]]'' mutation is synthetically lethal with a ''[[lytE]]'' mutation (due to a lack of autolysin activity) {{PubMed|23869552,23855774}} |
| − | * shorter, fatter cells {{PubMed|23855774}} | + | * shorter, fatter cells, this can be rescued by addition of Mg(2+) {{PubMed|23869552,23855774}} |
| + | * reduced growth rate, especially at low Mg(2+) concentrations {{PubMed|23869552}} | ||
=== Database entries === | === Database entries === | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' | + | * '''[[Domains]]:''' |
* '''Modification:''' | * '''Modification:''' | ||
| − | * ''' | + | * '''[[Cofactors]]:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[FtsE]]-[[FtsX]] {{PubMed|18573177}} | + | ** [[FtsE]]-[[FtsX]] {{PubMed|23869552,18573177}} |
** [[FloT]]-[[FtsX]] {{PubMed|23651456}} | ** [[FloT]]-[[FtsX]] {{PubMed|23651456}} | ||
| + | ** [[FtsX]]-[[CwlO]], at the membrane {{PubMed|23869552}} | ||
| − | * '''[[Localization]]:''' cell membrane | + | * '''[[Localization]]:''' |
| + | ** cell membrane {{PubMed|23869552}} | ||
=== Database entries === | === Database entries === | ||
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=References= | =References= | ||
| − | <pubmed>10092453,18573177,23651456,14651647,18763711, 23855774</pubmed> | + | <pubmed>10092453,18573177,23651456,14651647,18763711, 23855774 23869552</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 19:35, 14 December 2013
- Description: ABC transporter (membrane protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation
| Gene name | ftsX |
| Synonyms | |
| Essential | no |
| Product | ABC transporter (membrane protein) |
| Function | control of cell wall synthesis |
| Gene expression levels in SubtiExpress: ftsX | |
| Interactions involving this protein in SubtInteract: FtsX | |
| MW, pI | 32 kDa, 10.016 |
| Gene length, protein length | 888 bp, 296 aa |
| Immediate neighbours | ctpB, ftsE |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
ABC transporters, cell wall synthesis, phosphorelay, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU35250
Phenotypes of a mutant
- a ftsX mutation is synthetically lethal with a lytE mutation (due to a lack of autolysin activity) PubMed
- shorter, fatter cells, this can be rescued by addition of Mg(2+) PubMed
- reduced growth rate, especially at low Mg(2+) concentrations PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Protein family: FtsX subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Modification:
- Effectors of protein activity:
- Localization:
- cell membrane PubMed
Database entries
- Structure:
- UniProt: O34876
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
