CotH

• Description: spore coat protein (inner), required for the assembly of several outer coat proteins
  
  

Gene name	cotH
Synonyms	ywrH
Essential	no
Product	spore coat protein (inner)
Function	protection of CotU and CotC in the mother cell
Gene expression levels in SubtiExpress: cotH
MW, pI	42 kDa, 5.953
Gene length, protein length	1086 bp, 362 aa
Immediate neighbours	cotB, cotG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

GerE regulon, SigK regulon

The gene

Basic information

• Locus tag: BSU36060

Phenotypes of a mutant

• overexpression of cotH suppresses the phenotypes of a cotE mutant PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: cotH family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • spore wall (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q45535

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: cotH PubMed

• Expression browser: cotH PubMed

• Sigma factor: SigK PubMed

• Regulation:
  • expressed late during sporulation in the mother cell (SigK, GerE) PubMed

• Regulatory mechanism:
  • GerE: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: