LiaH

• Description: similar to phage shock protein, resistance against oxidative stress and cell wall antibiotics (such as daptamycin)
  
  

Gene name	liaH
Synonyms	yvqH
Essential	no
Product	unknown
Function	resistance against oxidative stress and cell wall antibiotics
Gene expression levels in SubtiExpress: liaH
MW, pI	25 kDa, 6.172
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	liaG, liaI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

• Locus tag: BSU33120

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pspA/IM30 family (according to Swiss-Prot)

• Paralogous protein(s): PspA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • forms large oligomeric rings with a nine-fold rotational symmetry PubMed

• Localization: variable (spotty) protein PubMed

Database entries

• Structure:

• UniProt: O32201

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaI-liaH PubMed

• Expression browser: liaH PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by bacitracin and rhamnolipids (LiaR) PubMed
  • repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed

• Regulatory mechanism:
  • LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: