Difference between revisions of "TcyP"

From SubtiWiki
Jump to: navigation, search
Line 21: Line 21:
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1389 bp, 463 aa  
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1389 bp, 463 aa  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yhcK]]'', ''[[yhcM]]''
+
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dgcK]]'', ''[[yhcM]]''
 
|-
 
|-
 
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU09130 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU09130 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU09130 DNA_with_flanks]
 
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU09130 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU09130 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU09130 DNA_with_flanks]
Line 36: Line 36:
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
<br/><br/><br/><br/>
+
<br/><br/>
<br/><br/><br/><br/>
 
 
 
 
 
<br/><br/><br/><br/><br/><br/>
 
  
 
= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
Line 114: Line 110:
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=tcyP_986986_988377_1 tcyP] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=tcyP_986986_988377_1 tcyP] {{PubMed|22383849}}
  
* '''Sigma factor:'''  
+
* '''[[Sigma factor]]:'''  
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  

Revision as of 10:27, 10 August 2013

  • Description: cystine transporter, membrane protein

Gene name tcyP
Synonyms yhcL
Essential no
Product cystine transporter, membrane protein
Function cystine uptake
Gene expression levels in SubtiExpress: tcyP
Metabolic function and regulation of this protein in SubtiPathways:
Ammonium/ glutamate
MW, pI 48 kDa, 9.471
Gene length, protein length 1389 bp, 463 aa
Immediate neighbours dgcK, yhcM
Sequences Protein DNA DNA_with_flanks
Genetic context
YhcL context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TcyP expression.png















Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CymR regulon

The gene

Basic information

  • Locus tag: BSU09130

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: cystine-proton symporter PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information: K(m) = 0.6 myM PubMed
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: tcyP
  • Regulation:
    • repressed in the presence of sulfate or cysteine (CymR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Isabelle Martin-Verstraete, Institute Pasteur, Paris, France

Your additional remarks

References

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

Sergine Even, Pierre Burguière, Sandrine Auger, Olga Soutourina, Antoine Danchin, Isabelle Martin-Verstraete
Global control of cysteine metabolism by CymR in Bacillus subtilis.
J Bacteriol: 2006, 188(6);2184-97
[PubMed:16513748] [WorldCat.org] [DOI] (P p)

Pierre Burguière, Sandrine Auger, Marie-Françoise Hullo, Antoine Danchin, Isabelle Martin-Verstraete
Three different systems participate in L-cystine uptake in Bacillus subtilis.
J Bacteriol: 2004, 186(15);4875-84
[PubMed:15262924] [WorldCat.org] [DOI] (P p)

Sandrine Auger, Antoine Danchin, Isabelle Martin-Verstraete
Global expression profile of Bacillus subtilis grown in the presence of sulfate or methionine.
J Bacteriol: 2002, 184(18);5179-86
[PubMed:12193636] [WorldCat.org] [DOI] (P p)