Difference between revisions of "MutS"
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| + | * 60-fold increased mutation rate {{PubMed|23882084}} | ||
| + | * a ''[[rnhB]] [[mutS]]-[[mutL]]'' mutant is not viable {{PubMed|23882084}} | ||
=== Database entries === | === Database entries === | ||
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=Biological materials = | =Biological materials = | ||
| − | * '''Mutant:''' GP1190 (del '' | + | * '''Mutant:''' |
| + | ** GP1190 (del ''[[mutS]]-[[mutL]]''::''aphA3'') available in [[Jörg Stülke]]'s lab | ||
** 1A833 ( ''mutS''::''spec''), {{PubMed|11779496}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A833&Search=1A833 BGSC] | ** 1A833 ( ''mutS''::''spec''), {{PubMed|11779496}}, available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A833&Search=1A833 BGSC] | ||
| Line 140: | Line 143: | ||
=References= | =References= | ||
| − | <pubmed>8760914, 15375129,16479537 20525796 20453097 23228104 21958350</pubmed> | + | <pubmed>8760914, 15375129,16479537 20525796 20453097 23228104 21958350 23882084</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 15:59, 25 July 2013
- Description: DNA mismatch repair (mismatch recognition protein)
| Gene name | mutS |
| Synonyms | |
| Essential | no |
| Product | mismatch recognition protein |
| Function | DNA repair |
| Gene expression levels in SubtiExpress: mutS | |
| Interactions involving this protein in SubtInteract: MutS | |
| MW, pI | 97 kDa, 5.189 |
| Gene length, protein length | 2574 bp, 858 aa |
| Immediate neighbours | cotE, mutL |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17040
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- MutS recognizes mismatches in the DNA and recruits MutL to the site of mismatch recognition
- Protein family: DNA mismatch repair mutS family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P49849
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
- An antisense RNA is predicted for mutS PubMed
Biological materials
- Mutant:
- GP1190 (del mutS-mutL::aphA3) available in Jörg Stülke's lab
- 1A833 ( mutS::spec), PubMed, available at BGSC
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
