Difference between revisions of "HisB"
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Revision as of 14:40, 16 May 2013
- Description: imidazoleglycerol-phosphate dehydratase
| Gene name | hisB |
| Synonyms | |
| Essential | no |
| Product | imidazoleglycerol-phosphate dehydratase |
| Function | biosynthesis of histidine |
| Gene expression levels in SubtiExpress: hisB | |
| Metabolic function and regulation of this protein in SubtiPathways: His | |
| MW, pI | 21 kDa, 5.598 |
| Gene length, protein length | 582 bp, 194 aa |
| Immediate neighbours | hisH, hisD |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
| Expression at a glance PubMed 500px | |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU34900
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (according to Swiss-Prot)
- Protein family: imidazoleglycerol-phosphate dehydratase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 2AE8 (from Staphylococcus aureus subsp. aureus n315 mutant, 48% identity, 65% similarity)
- UniProt: O34683
- KEGG entry: [2]
- E.C. number: 4.2.1.19
Additional information
Expression and regulation
- Sigma factor:
- Regulation: repressed by casamino acids PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
