Difference between revisions of "CatR"

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Revision as of 14:35, 16 May 2013

Gene name catR
Synonyms yvaP
Essential no
Product MarR/DUF24 family transcription repressor
Function resistance against oxidative and electrophile stress
Gene expression levels in SubtiExpress: catR
MW, pI 26 kDa, 9.887
Gene length, protein length 708 bp, 236 aa
Immediate neighbours yvaO, yvaQ
Sequences Protein DNA DNA_with_flanks
Genetic context
YvaP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CatR expression.png
























Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

The CatR regulon:

catD-catE

The gene

Basic information

  • Locus tag: BSU33680

Phenotypes of a mutant

increased resistance to catechol and quinones PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Paralogous protein(s): YodB

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: in responsse to the presence of diamides or quinones, Cys-7 forms intermolecular disulfide bonds, this results in loss of DNA-bindig ability (induction of catD-catE) PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Haike Antelmann,University of Greifswald, Germany

Your additional remarks

References

Reviews

Antelmann H, Helmann JD.
Thiol-based redox switches and gene regulation.
Antioxid Redox Signal. 2011,14:1049-63.
PubMed

Haike Antelmann, Michael Hecker, Peter Zuber
Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.
Expert Rev Proteomics: 2008, 5(1);77-90
[PubMed:18282125] [WorldCat.org] [DOI] (I p)


Original Articles