Difference between revisions of "SppA"
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Revision as of 14:18, 16 May 2013
- Description: signal peptide peptidase required for efficient processing of pre-proteins
Gene name | sppA |
Synonyms | yteI |
Essential | no |
Product | signal peptide peptidase |
Function | protein secretion |
Gene expression levels in SubtiExpress: sppA | |
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
MW, pI | 36 kDa, 7.314 |
Gene length, protein length | 1005 bp, 335 aa |
Immediate neighbours | yteJ, ytdI |
Sequences | Protein DNA DNA_with_flanks |
Genetic context ![]() This image was kindly provided by SubtiList
| |
Expression at a glance PubMed![]() |
Contents
Categories containing this gene/protein
protein secretion, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU29530
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- serine protease that functions to cleave the remnant signal peptides left behind after protein secretion and cleavage by signal peptidases
- Protein family: peptidase S49 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- the protein forms a dome shaped octameric complex PubMed
- Localization:
- cell membrane PubMed
Database entries
- UniProt: O34525
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Sung-Eun Nam, Apollos C Kim, Mark Paetzel
Crystal structure of Bacillus subtilis signal peptide peptidase A.
J Mol Biol: 2012, 419(5);347-58
[PubMed:22472423]
[WorldCat.org]
[DOI]
(I p)
Min Cao, Tao Wang, Rick Ye, John D Helmann
Antibiotics that inhibit cell wall biosynthesis induce expression of the Bacillus subtilis sigma(W) and sigma(M) regulons.
Mol Microbiol: 2002, 45(5);1267-76
[PubMed:12207695]
[WorldCat.org]
[DOI]
(P p)
X Huang, A Gaballa, M Cao, J D Helmann
Identification of target promoters for the Bacillus subtilis extracytoplasmic function sigma factor, sigma W.
Mol Microbiol: 1999, 31(1);361-71
[PubMed:9987136]
[WorldCat.org]
[DOI]
(P p)