Difference between revisions of "LonA"

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Revision as of 14:11, 16 May 2013

  • Description: class III heat-shock ATP-dependent protease

Gene name lonA
Synonyms lon
Essential no
Product class III heat-shock ATP-dependent protease
Function protein quality control
Gene expression levels in SubtiExpress: lonA
Regulation of this protein in SubtiPathways:
Stress
MW, pI 86 kDa, 5.774
Gene length, protein length 2322 bp, 774 aa
Immediate neighbours ysxC, lonB
Sequences Protein DNA DNA_with_flanks
Genetic context
LonA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LonA expression.png















Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

CtsR regulon

The gene

Basic information

  • Locus tag: BSU28200

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

A mutation in lonA suppresses the motility defect of a lytC mutant PubMed

Evidence for a specific DNA binding activitity of the α-domain was found PubMed


The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Hydrolysis of proteins in presence of ATP (according to Swiss-Prot)
  • Protein family: peptidase S16 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: coincident with the nucleoid during normal growth and localized to the forespore during development PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Additional reviews: PubMed

Original publications