Difference between revisions of "SlrA"
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywcC]]'', ''[[ywcB]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywcC]]'', ''[[ywcB]]'' | ||
|- | |- | ||
| − | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38229 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38229 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38229 | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38229 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38229 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38229 DNA_with_flanks] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ywcC_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ywcC_context.gif]] | ||
Revision as of 11:35, 14 May 2013
- Description: anti-repressor, antagonist of SinR and SlrR, involved in control of flagellar genes and eps and tapA-sipW-tasA operons
| Gene name | slrA |
| Synonyms | |
| Essential | no |
| Product | antagonist of SinR and SlrR |
| Function | control of biofilm formation |
| Gene expression levels in SubtiExpress: slrA | |
| Interactions involving this protein in SubtInteract: SlrA | |
| Regulation of this protein in SubtiPathways: Biofilm | |
| MW, pI | 6.1 kDa, 9.992 |
| Gene length, protein length | 156 bp, 52 aa |
| Immediate neighbours | ywcC, ywcB |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transcription factors and their control, transition state regulators, biofilm formation
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU38229
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry:
Additional information
- This gene was only recently identified. PubMed
- SlrA overexpression results in reduced expression of the SigD regulon and in enhanced expression of the SinR regulon, this can be suppressed by inactivation of either remA, remB, slrR, or sinR PubMed
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binding of SinR resulting in induction of SinR-repressed genes and operons PubMed
- Protein family:
- Paralogous protein(s): SinI
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
Database entries
- Structure:
- UniProt: P0C8M5
- KEGG entry: no entry
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Joseph A Newman, Cecilia Rodrigues, Richard J Lewis
Molecular basis of the activity of SinR protein, the master regulator of biofilm formation in Bacillus subtilis.
J Biol Chem: 2013, 288(15);10766-78
[PubMed:23430750]
[WorldCat.org]
[DOI]
(I p)
Yunrong Chai, Roberto Kolter, Richard Losick
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.
Mol Microbiol: 2009, 74(4);876-87
[PubMed:19788541]
[WorldCat.org]
[DOI]
(I p)
Kazuo Kobayashi
SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 69(6);1399-410
[PubMed:18647168]
[WorldCat.org]
[DOI]
(I p)
