Difference between revisions of "QoxD"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywcE]]'', ''[[qoxC]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywcE]]'', ''[[qoxC]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38140 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38140 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38140 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38140 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38140 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38140 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:qoxD_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:qoxD_context.gif]]

Revision as of 11:35, 14 May 2013

  • Description: cytochrome aa3 quinol oxidase (subunit IV)

Gene name qoxD
Synonyms ipa-40d
Essential no
Product cytochrome aa3 quinol oxidase (subunit IV)
Function respiration
Gene expression levels in SubtiExpress: qoxD
MW, pI 13 kDa, 5.942
Gene length, protein length 372 bp, 124 aa
Immediate neighbours ywcE, qoxC
Sequences Protein DNA DNA_with_flanks
Genetic context
QoxD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
QoxD expression.png
























Categories containing this gene/protein

respiration, membrane proteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU38140

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Ubiquinol-8 + O2 = Ubiquinone-8 + H2O (according to Swiss-Prot)
  • Protein family: cytochrome c oxidase bacterial subunit 4 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Sophia M Yi, Kuppala V Narasimhulu, Rimma I Samoilova, Robert B Gennis, Sergei A Dikanov
Characterization of the semiquinone radical stabilized by the cytochrome aa3-600 menaquinol oxidase of Bacillus subtilis.
J Biol Chem: 2010, 285(24);18241-51
[PubMed:20351111] [WorldCat.org] [DOI] (I p)

L Winstedt, C von Wachenfeldt
Terminal oxidases of Bacillus subtilis strain 168: one quinol oxidase, cytochrome aa(3) or cytochrome bd, is required for aerobic growth.
J Bacteriol: 2000, 182(23);6557-64
[PubMed:11073895] [WorldCat.org] [DOI] (P p)

N Azarkina, S Siletsky, V Borisov, C von Wachenfeldt, L Hederstedt, A A Konstantinov
A cytochrome bb'-type quinol oxidase in Bacillus subtilis strain 168.
J Biol Chem: 1999, 274(46);32810-7
[PubMed:10551842] [WorldCat.org] [DOI] (P p)

M Santana, F Kunst, M F Hullo, G Rapoport, A Danchin, P Glaser
Molecular cloning, sequencing, and physiological characterization of the qox operon from Bacillus subtilis encoding the aa3-600 quinol oxidase.
J Biol Chem: 1992, 267(15);10225-31
[PubMed:1316894] [WorldCat.org] (P p)