Fnr

• Description: transcriptional regulator of anaerobic genes
  
  

Gene name	fnr
Synonyms
Essential	no
Product	transcription regulator (Crp family)
Function	regulation of anaerobiosis, fermentation and overflow metabolism
Gene expression levels in SubtiExpress: fnr
Metabolic function and regulation of this protein in SubtiPathways: Alternative nitrogen sources
MW, pI	27 kDa, 5.989
Gene length, protein length	714 bp, 238 aa
Immediate neighbours	ywiC, narK
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

regulators of electron transport, transcription factors and their control

This gene is a member of the following regulons

Fnr regulon, NsrR regulon, ResD regulon

The gene

Basic information

• Locus tag: BSU37310

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: contains an iron-sulfur cluster

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P46908

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • narK-fnr PubMed
  • fnr PubMed

• Expression browser: fnr PubMed

• Sigma factor:
  • narK: SigA PubMed
  • fnr: SigA PubMed

• Regulation:
  • narK: expressed under anaerobic conditions (Fnr) PubMed
  • fnr: expressed under anaerobic conditions (ResD) PubMed
  • induced by nitric oxide under anaerobic conditions (NsrR) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • NsrR: transcription repression PubMed
  • Fnr: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Elisabeth Härtig, Dieter Jahn
Regulation of the anaerobic metabolism in Bacillus subtilis.
Adv Microb Physiol: 2012, 61;195-216
[PubMed:23046954] [WorldCat.org] [DOI] (I p)

The Fnr regulon

Heike Reents, Richard Münch, Thorben Dammeyer, Dieter Jahn, Elisabeth Härtig
The Fnr regulon of Bacillus subtilis.
J Bacteriol: 2006, 188(3);1103-12
[PubMed:16428414] [WorldCat.org] [DOI] (P p)