SknR

• Description: transcription repressor of the yqaF-yqdA-yqaG-yqaH-yqaI-yqaJ-yqaK-yqaL-yqaM-yqaN operon of the skin element (Xre family)
  
  

Gene name	sknR
Synonyms	yqaE
Essential	yes PubMed
Product	transcription repressor
Function	control of prophage gene expression
Gene expression levels in SubtiExpress: sknR
MW, pI	13 kDa, 5.42
Gene length, protein length	348 bp, 116 aa
Immediate neighbours	yqaF, yqaD
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, Skin element, essential genes

The gene

Basic information

• Locus tag: BSU26350

Phenotypes of a mutant

• essential in the wild type background (due to overexpression of the toxic proteins YqaH and YqaM) PubMed
• no phenotype if deleted with the complete skin element PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: binds the yqaF promoter region to repress transcription of the yqaF-yqdA-yqaG-yqaH-yqaI-yqaJ-yqaK-yqaL-yqaM-yqzO-yqaN operon PubMed

• Protein family:

• Paralogous protein(s): YonR, Xre

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P45902

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: sknR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Tatsu Kimura, Yukie Amaya, Kazuo Kobayashi, Naotake Ogasawara, Tsutomu Sato
Repression of sigK intervening (skin) element gene expression by the CI-like protein SknR and effect of SknR depletion on growth of Bacillus subtilis cells.
J Bacteriol: 2010, 192(23);6209-16
[PubMed:20889742] [WorldCat.org] [DOI] (I p)