Difference between revisions of "MtnA"

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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ogt]]'', ''[[mtnK]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ogt]]'', ''[[mtnK]]''
 
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13550 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13550 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13550 Advanced_DNA]
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13550 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13550 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13550 DNA_with_flanks]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:ykrS_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ykrS_context.gif]]

Revision as of 10:02, 14 May 2013

  • Description: 5-methylthioribose-1-phosphate isomerase

Gene name mtnA
Synonyms ykrS, mtnS
Essential no
Product 5-methylthioribose-1-phosphate isomerase
Function methionine salvage
Gene expression levels in SubtiExpress: mtnA
Metabolic function and regulation of this protein in SubtiPathways:
Cys, Met & Sulfate assimilation
MW, pI 38 kDa, 5.003
Gene length, protein length 1059 bp, 353 aa
Immediate neighbours ogt, mtnK
Sequences Protein DNA DNA_with_flanks
Genetic context
YkrS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MtnA expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, phosphoproteins

This gene is a member of the following regulons

S-box

The gene

Basic information

  • Locus tag: BSU13550

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate (according to Swiss-Prot)
  • Protein family: MtnA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-80 and Arg-298 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
  • Regulatory mechanism: S-box: transcription termination/ antitermination, the S-box riboswitch binds S-adenosylmethionine resulting in termination PubMed
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References