Difference between revisions of "DltA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
 
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of teichoic acid
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU38500 dltA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38500 dltA]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 55 kDa, 4.929   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 55 kDa, 4.929   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywzH]]'', ''[[dltB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywzH]]'', ''[[dltB]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15876&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38500 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38500 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38500 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:dltA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:dltA_context.gif]]

Revision as of 14:11, 13 May 2013

  • Description: D-alanyl-D-alanine carrier protein ligase, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Gene name dltA
Synonyms ipa-5r, dae
Essential no
Product D-alanyl-D-alanine carrier protein ligase
Function biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: dltA
MW, pI 55 kDa, 4.929
Gene length, protein length 1509 bp, 503 aa
Immediate neighbours ywzH, dltB
Sequences Protein DNA Advanced_DNA
Genetic context
DltA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DltA expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon

The gene

Basic information

  • Locus tag: BSU38500

Phenotypes of a mutant

    • increased sensitivity to lysozyme PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate) (according to Swiss-Prot)
  • Protein family: DltA subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • expression is reduced in a SigV mutant PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Mohamed Marahiel, Marburg University, Germany homepage

Your additional remarks

References

Additional publications: PubMed