Difference between revisions of "SasA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || ppGpp synthesis independent from stringent response
 
|style="background:#ABCDEF;" align="center"|'''Function''' || ppGpp synthesis independent from stringent response
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU38480 ywaC]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU38480 ywaC]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 6.217   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 24 kDa, 6.217   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywaD]]'', ''[[menA]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ywaD]]'', ''[[menA]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB15874&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU38480 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU38480 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU38480 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:ywaC_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:ywaC_context.gif]]

Revision as of 14:11, 13 May 2013

  • Description: (p)ppGpp synthetase, small alarmone synthetase

Gene name ywaC
Synonyms ipa-7d
Essential no
Product (p)ppGpp synthetase
Function ppGpp synthesis independent from stringent response
Gene expression levels in SubtiExpress: ywaC
MW, pI 24 kDa, 6.217
Gene length, protein length 630 bp, 210 aa
Immediate neighbours ywaD, menA
Sequences Protein DNA Advanced_DNA
Genetic context
YwaC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YwaC expression.png















Categories containing this gene/protein

metabolism of signalling nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon SigW regulon

The gene

Basic information

  • Locus tag: BSU38480

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): YjbM

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes tagB, tagD and tagF, and also in response to cell-wall-active compounds like bacitracin or vancomycin PubMed
    • expression is reduced in a SigV mutant PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed