Difference between revisions of "GlyA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of glycine | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of glycine | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU36900 glyA] |
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/ala_gly_ser.html Ala, Gly, Ser]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/ala_gly_ser.html Ala, Gly, Ser]''' | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[upp]]'', ''[[ywlG]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[upp]]'', ''[[ywlG]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU36900 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU36900 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU36900 Advanced_DNA] |
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|colspan="2" | '''Genetic context''' <br/> [[Image:glyA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:glyA_context.gif]] | ||
Revision as of 14:05, 13 May 2013
- Description: serine hydroxymethyltransferase
| Gene name | glyA |
| Synonyms | glyC, ipc-34d |
| Essential | yes PubMed |
| Product | serine hydroxymethyltransferase |
| Function | biosynthesis of glycine |
| Gene expression levels in SubtiExpress: glyA | |
| Metabolic function and regulation of this protein in SubtiPathways: Ala, Gly, Ser | |
| MW, pI | 45 kDa, 5.475 |
| Gene length, protein length | 1245 bp, 415 aa |
| Immediate neighbours | upp, ywlG |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids, essential genes, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU36900
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine (according to Swiss-Prot)
- Protein family: SHMT family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 2VGU (complex with L-serine, Geobacillus stearothermophilus), 2VI8 (Geobacillus stearothermophilus)
- UniProt: P39148
- KEGG entry: [3]
- E.C. number: 2.1.2.1
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- T-box: RNA switch, transcriptional antitermination PubMed
- PurR: transcription repression (molecular inducer: PRPP) PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
