Difference between revisions of "StoA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || spore cortex formation | |style="background:#ABCDEF;" align="center"|'''Function''' || spore cortex formation | ||
|- | |- | ||
| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU13840 stoA] |
|- | |- | ||
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/StoA StoA] | |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/StoA StoA] | ||
| Line 24: | Line 24: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykvU]]'', ''[[zosA]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ykvU]]'', ''[[zosA]]'' | ||
|- | |- | ||
| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13840 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13840 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13840 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:ykvV_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ykvV_context.gif]] | ||
Revision as of 12:40, 13 May 2013
- Description: thiol-disulfide oxidoreductase, with thioredoxin-like domain, required for the synthesis of the endospore peptidoglycan cortex
| Gene name | stoA |
| Synonyms | spoIVH, ykvV |
| Essential | no |
| Product | thiol-disulfide oxidoreductase |
| Function | spore cortex formation |
| Gene expression levels in SubtiExpress: stoA | |
| Interactions involving this protein in SubtInteract: StoA | |
| MW, pI | 18 kDa, 5.297 |
| Gene length, protein length | 495 bp, 165 aa |
| Immediate neighbours | ykvU, zosA |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13840
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: reduction of intramolecular disulfide bonds in SpoVD PubMed
- Protein family: thioredoxin domain (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- forespore envelope PubMed
Database entries
- Structure: 3ERW
- UniProt: O31687
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Lars Hederstedt, University of Lund, Sweden Homepage
Your additional remarks
References
Reviews
Patrick Eichenberger
The red-ox status of a penicillin-binding protein is an on/off switch for spore peptidoglycan synthesis in Bacillus subtilis.
Mol Microbiol: 2010, 75(1);10-2
[PubMed:19919674]
[WorldCat.org]
[DOI]
(I p)
Original Publications
Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796]
[WorldCat.org]
[DOI]
(I p)
Yiming Liu, Mirja Carlsson Möller, Lise Petersen, Christopher A G Söderberg, Lars Hederstedt
Penicillin-binding protein SpoVD disulphide is a target for StoA in Bacillus subtilis forespores.
Mol Microbiol: 2010, 75(1);46-60
[PubMed:19919673]
[WorldCat.org]
[DOI]
(I p)
Allister Crow, Yiming Liu, Mirja Carlsson Möller, Nick E Le Brun, Lars Hederstedt
Structure and functional properties of Bacillus subtilis endospore biogenesis factor StoA.
J Biol Chem: 2009, 284(15);10056-66
[PubMed:19144642]
[WorldCat.org]
[DOI]
(P p)
Lyethur S Erlendsson, Mirja Möller, Lars Hederstedt
Bacillus subtilis StoA Is a thiol-disulfide oxidoreductase important for spore cortex synthesis.
J Bacteriol: 2004, 186(18);6230-8
[PubMed:15342593]
[WorldCat.org]
[DOI]
(P p)
Daisuke Imamura, Kazuo Kobayashi, Junichi Sekiguchi, Naotake Ogasawara, Michio Takeuchi, Tsutomu Sato
spoIVH (ykvV), a requisite cortex formation gene, is expressed in both sporulating compartments of Bacillus subtilis.
J Bacteriol: 2004, 186(16);5450-9
[PubMed:15292147]
[WorldCat.org]
[DOI]
(P p)
Patrick Eichenberger, Shane T Jensen, Erin M Conlon, Christiaan van Ooij, Jessica Silvaggi, José Eduardo González-Pastor, Masaya Fujita, Sigal Ben-Yehuda, Patrick Stragier, Jun S Liu, Richard Losick
The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.
J Mol Biol: 2003, 327(5);945-72
[PubMed:12662922]
[WorldCat.org]
[DOI]
(P p)
