Difference between revisions of "NhaC"

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|style="background:#ABCDEF;" align="center"|'''Function''' || pH homeostasis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || pH homeostasis
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU09680 nhaC]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU09680 nhaC]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 7.874   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 47 kDa, 7.874   
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dat]]'', ''[[nhaX]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[dat]]'', ''[[nhaX]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB12807&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU09680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU09680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU09680 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:nhaC_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:nhaC_context.gif]]

Revision as of 12:27, 13 May 2013

  • Description: Na+/H+ antiporter

Gene name nhaC
Synonyms yheL
Essential no
Product Na+/H+ antiporter
Function pH homeostasis
Gene expression levels in SubtiExpress: nhaC
MW, pI 47 kDa, 7.874
Gene length, protein length 1359 bp, 453 aa
Immediate neighbours dat, nhaX
Sequences Protein DNA Advanced_DNA
Genetic context
NhaC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NhaC expression.png
























Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), pH homeostasis, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09680

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: nhaC Na(+)/H(+) antiporter family (according to Swiss-Prot)
  • Paralogous protein(s): MleN

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
    • NhaX: transcription activation (probably) PubMed
  • Additional information:
    • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947