Difference between revisions of "HypO"
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|style="background:#ABCDEF;" align="center"|'''Function''' || protection against NaOCl stress | |style="background:#ABCDEF;" align="center"|'''Function''' || protection against NaOCl stress | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU07830 hypO] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 5.667 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 25 kDa, 5.667 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[treR]]'', ''[[yfkN]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[treR]]'', ''[[yfkN]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU07830 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU07830 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU07830 Advanced_DNA] |
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|colspan="2" | '''Genetic context''' <br/> [[Image:yfkO_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yfkO_context.gif]] | ||
Revision as of 12:21, 13 May 2013
- Description: NAD(P)H-flavin nitroreductase
| Gene name | hypO |
| Synonyms | yfkO |
| Essential | no |
| Product | NAD(P)H-flavin nitroreductase |
| Function | protection against NaOCl stress |
| Gene expression levels in SubtiExpress: hypO | |
| MW, pI | 25 kDa, 5.667 |
| Gene length, protein length | 663 bp, 221 aa |
| Immediate neighbours | treR, yfkN |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
electron transport/ other, resistance against oxidative and electrophile stress
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU07830
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: nitroreductase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: O34475
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: hypO PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
- Haike Antelmann, University of Greifswald, Germany
Your additional remarks
References
Original articles
G A Prosser, A V Patterson, D F Ackerley
uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.
J Biotechnol: 2010, 150(1);190-4
[PubMed:20727918]
[WorldCat.org]
[DOI]
(I p)
Palm GJ, Khanh Chi B, Waack P, Gronau K, Becher D, Albrecht D, Hinrichs W, Read RJ, Antelmann H. Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR. Nucleic Acids Res. 2012, Jan 11. [Epub ahead of print] PubMed
