Difference between revisions of "KtrA"
| Line 92: | Line 92: | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
| − | ** [[KtrA]]-[[KtrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed] | + | ** [[KtrA]]-[[KtrB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed], composed of an octameric [[KtrA]] ring and two [[KtrB]] dimers {{PubMed|23598340}} |
* '''[[Localization]]:''' peripheral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed] | * '''[[Localization]]:''' peripheral membrane protein [http://www.ncbi.nlm.nih.gov/sites/entrez/12562800 PubMed] | ||
| Line 98: | Line 98: | ||
=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1LSU 1LSU] (complex with NADH) | + | * '''Structure:''' |
| + | ** [http://www.rcsb.org/pdb/explore.do?structureId=1LSU 1LSU] (complex with NADH) | ||
| + | ** [http://www.proteopedia.org/wiki/index.php/2hmw 2HMW] ( complex with ATP) | ||
| + | ** [http://www.pdb.org/pdb/explore/explore.do?structureId=4J7C 4J7C] (the [[KtrA]]-[[KtrB]] complex) {{PubMed|23598340}} | ||
* '''UniProt:''' [http://www.uniprot.org/uniprot/O32080 O32080] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O32080 O32080] | ||
| Line 114: | Line 117: | ||
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ktrA_3188414_3189082_1 ktrA] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ktrA_3188414_3189082_1 ktrA] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 147: | Line 150: | ||
=References= | =References= | ||
| − | <pubmed>12562800,15096624, 20511502, 23086297</pubmed> | + | <pubmed>12562800,15096624, 20511502, 23086297 23598340 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 08:06, 22 April 2013
- Description: high affinity potassium transporter KtrA-KtrB, peripheric membrane component (proton symport)
| Gene name | ktrA |
| Synonyms | yuaA |
| Essential | no |
| Product | high affinity potassium transporter KtrA-KtrB, peripheric membrane component (proton symport) |
| Function | potassium uptake |
| Gene expression levels in SubtiExpress: ktrA | |
| Interactions involving this protein in SubtInteract: KtrA | |
| Metabolic function and regulation of this protein in SubtiPathways: Metal ion homeostasis, Stress | |
| MW, pI | 24 kDa, 5.981 |
| Gene length, protein length | 666 bp, 222 aa |
| Immediate neighbours | bslA, ktrB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU31090
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s): KtrC
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: peripheral membrane protein PubMed
Database entries
- UniProt: O32080
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- induced if the energy charge is low (ydaO riboswitch) PubMed
- Regulatory mechanism:
- expression is controlled via termination antitermination by the ydaO riboswitch PubMed
- Additional information:
Biological materials
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Erhard Bremer, University of Marburg, Germany homepage
Your additional remarks
References
Ricardo S Vieira-Pires, Andras Szollosi, João H Morais-Cabral
The structure of the KtrAB potassium transporter.
Nature: 2013, 496(7445);323-8
[PubMed:23598340]
[WorldCat.org]
[DOI]
(I p)
Peter Y Watson, Martha J Fedor
The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis.
Nat Chem Biol: 2012, 8(12);963-5
[PubMed:23086297]
[WorldCat.org]
[DOI]
(I p)
Kirsten F Block, Ming C Hammond, Ronald R Breaker
Evidence for widespread gene control function by the ydaO riboswitch candidate.
J Bacteriol: 2010, 192(15);3983-9
[PubMed:20511502]
[WorldCat.org]
[DOI]
(I p)
Jeffrey E Barrick, Keith A Corbino, Wade C Winkler, Ali Nahvi, Maumita Mandal, Jennifer Collins, Mark Lee, Adam Roth, Narasimhan Sudarsan, Inbal Jona, J Kenneth Wickiser, Ronald R Breaker
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.
Proc Natl Acad Sci U S A: 2004, 101(17);6421-6
[PubMed:15096624]
[WorldCat.org]
[DOI]
(P p)
Gudrun Holtmann, Evert P Bakker, Nobuyuki Uozumi, Erhard Bremer
KtrAB and KtrCD: two K+ uptake systems in Bacillus subtilis and their role in adaptation to hypertonicity.
J Bacteriol: 2003, 185(4);1289-98
[PubMed:12562800]
[WorldCat.org]
[DOI]
(P p)
